What’s accepted is not always appropriate!

Clade size is not always an appropriate measure of diversification.

Lanfear et al. [1] reported an interesting association between mutation rate and net diversification in birds that had not been as evident in other groups of organisms. More specifically, their data showed a correlation between synonymous substitution rate and net diversification that cannot be explained by selection, effective population size, or some plausibly covarying life-history trait. To...

Less is not always more: embracing (appropriate) medical intensity.

To cite: Burke LG, Jha AK. BMJ Qual Saf Published Online First: [please include Day Month Year] doi:10.1136/bmjqs-2014003586 As healthcare costs continue to rise globally, policy makers and researchers have focused on inefficiencies in healthcare delivery. In the USA, the combination of high costs and disappointing outcomes associated with a fragmented delivery system has generated the idea tha...

Small is not always beautiful

Peer-to-peer content distribution systems have been enjoying great popularity, and are now gaining momentum as a means of disseminating video streams over the Internet. In many of these protocols, including the popular BitTorrent, content is split into mostly fixed-size pieces, allowing a client to download data from many peers simultaneously. This makes piece size potentially critical for perf...

Promiscuity is not always bad.

In the recent issue of Cell, Bonham et al. (2014) reveal that the sorting adaptor TIRAP regulates the assembly of the Myddosome upon Toll-like receptor activation from both the cell surface and endosomes through its promiscuous binding to lipids.

Multiple and Bilateral Primary Brain Hydatid Cyst Dowling Technique is not always Appropriate (Case Report)